The Charis Eng laboratory is seeking a highly motivated, self-driven postdoctoral research fellow for the Genomic Medicine Institute at Cleveland Clinic Lerner Research Institute. PTEN hamartoma tumor syndrome (PHTS) is molecularly defined as the presence of germline PTEN mutation. Why mutation of a single gene PTEN results in specific cancer risks and/or autism spectrum disorder (ASD) is unknown. The Eng lab seeks modifiers from genome seq which may help bifurcate cancer vs ASD clinical outcomes. The successful candidate will have demonstrated proficiency in bioinformatics, computational genomic epidemiology and/or data science.

This position will be co-advised by Dr. Eng (human genomicist) and Dr, Ni (computational biologist).

Principal Investigator: Charis Eng, MD, PhD; Ying Ni, PhD

Lerner Research Institute Department: Genomic Medicine Institute

Lab Research Topics:

• Inherited disorder PTEN hamartoma tumor syndrome (germline PTEN mutation)
• Computational genomic epidemiology
• Bioinformatics
• Omic modifier(s) of germline PTEN mutation
• Which bifurcate phenotypes
• For more information about the lab’s research, please visit: https://www.lerner.ccf.org/genomic-medicine/eng/#lab-investigator or contact Dr. Eng at [email protected].

Job Responsibilities:

• Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation
• Identification and characterization of modifiers interacting with PTEN mutation
• Integrative analysis of multi-omics data for feature selection
• Provide clear, detailed and thorough progress reports

Education:

• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD

Languages:

• English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

• Previous experience in a research or academic setting.  Graduate student experience meets this requirement.
• Scientific writing experience

Additional Preferred Qualities:

• PhD required
• Trained and proficient in bioinformatics, data science and or computational genomics
• Highly motivated and self-driven individual with exemplary work-ethic and ability to promote team-spirit/collegiality

Physical Requirements:

• Ability to perform work in a stationary position for extended periods
• Ability to operate a computer and other office equipment
• Ability to communicate and exchange accurate information
• Ability to distinguish color
• Manual dexterity to handle specimens and repair equipment
• Ability to lift and transport equipment or specimens weighing up to 20 pounds
• May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

• PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

• CV
• Research statement
• Three references (names and contacts)
• All application materials should be submitted directly via email to Dr. Charis Eng at [email protected].

Keywords: Postdoc, Research, LRI, Genomic Medicine Institute, Omic modifiers, Germline PTEN mutation