Summary

The Foulds laboratory is a dedicated translational and molecular oncology research program, rich with individual expertise and collaborative studies, which focuses on understanding mechanisms of endocrine therapy and CDK4/6 inhibitor resistance and generating new and optimizing current treatment strategies for ER+ breast cancer patients. In order to develop precision diagnostics, the lab is interested in delineating mechanisms of resistance to standard-of-care therapeutics and metastasis for mainly ER+ breast cancers with some work on triple-negative breast cancers. The successful applicant is expected to carry out independent experiments (after any needed hands-on training) and work in collaboration with other members of the laboratory. Selected methodologies include protein, RNA, and DNA isolation from cancer cells, chromatin immunoprecipitation, RNA-sequencing, immunoblotting, cell culture, and ex vivo patient-derived xenograft (PDX) organoid culture as desirable. The laboratory’s work involves breast cancer cell lines and state-of-the-art PDX mouse models. Cross-training and transparency among the team is highly encouraged and practiced.

Job Duties

• Prepares and conducts laboratory research experiments.
• Collects, compiles and analyzes data
• Conducts literature searches and summarizes information in an appropriate format for a particular study.
• Documents results of experiments.
• Selects, evaluates and applies techniques used in routine research.
• Prepares figures and assists in writing related to experiments performed.
• Maintains general lab environment that includes but not limited to, equipment maintenance and repairs, organization, and cleanliness of the lab.

Minimum Qualifications

• Bachelor's degree in a Basic Science or related field. Four years of related experience may substitute for degree requirement.
• One year of relevant experience.

Preferred Qualifications

• Master's degree in basic science or a related field.
• Experience with animal husbandry is preferred. The laboratory’s work involves cell lines and state-of-the-art mouse models. 
• Prior experiences in tissue culture and basic molecular biology techniques (e.g., PCR, DNA purification, Western blot, … etc) are required.
• Preferred Knowledge about molecular biology and cancer biology.