Research Assistant II- Brain Targeting Program

Harvard Medical School

Boston, MA

Job posting number: #7076518

Posted: March 29, 2021

Application Deadline: Open Until Filled

Job Description

About us:

The Wyss Institute’s mission is to transform healthcare and the environment by emulating the way nature builds. We harness the freedom of academia and the focus of industry in order to translate revolutionary technologies into commercial products and solutions. At the Wyss Institute, faculty from premier academic and clinical institutions, collaborate with staff scientists, postdocs, graduate students, industry experts, business development leaders, and entrepreneurs across disciplines to invent and de- risk new technologies that don’t just succeed at making it to the market – they disrupt it. We support research that universities, companies, and venture capital firms don’t fund because they view it as too risky. We prefer to use the word “challenging,” and we love challenges. For more information, visit: http://wyss.harvard.edu/



About you:

You are a collaborative, impact-focused problem solver who wants to be part of a dynamic team dedicated to creating and commercializing novel approaches to global challenges in healthcare and sustainability. You want the freedom to explore, to push the boundaries of what is possible, and to use your ambition to tackle challenging projects in a fast-paced, industry-focused environment without a lot of administrative hurdles. You enjoy working with diverse groups of people and leveraging your expertise to create innovations that can change the world



About the role:

We are looking for a talented Research Assistant to support the discovery and validation of novel antibody (Ab) shuttles that efficiently deliver therapeutic payloads across the blood-brain barrier (BBB). Reporting to the Senior Staff Scientist, you will work with a multidisciplinary team as part of our Bioinspired Therapeutics and Diagnostics platform. This team synergizes the strength of both in vitro cellular systems (Transwell, Human BBB Chip, and diverse related cellular assays) and in vivo humanized transgenic mouse models for compound discovery and validation. For more information, visit: https://wyss.harvard.edu/technology/brain-targeting-program-shuttles-for-brain-delivery-of- therapeutics-and-diagnostics/


Job-Specific Responsibilities

What you'll do:

Under guidance from senior staff, contribute significantly to efforts in novel drug and diagnostic delivery across the BBB.
Prepare mouse tissue and blood for pharmacokinetics and pharmacodynamic studies (PKPD)
Perform various protocols including plate-based ELISA assays, western blots, immunohistochemistry, cell-based assays, and flow cytometry
With supervision from senior staff analyze and interpret experimental data, learn new skills, troubleshoot, and contribute intellectually to the project
Order supplies, perform support activities and lab maintenance, and function in a team-oriented environment with other scientists and staff at the Institute as well as external collaborators
Assist with presenting data and conclusions at meetings within the Wyss Institute
Demonstrate a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others
Help train interns, doctoral students and post-doctoral trainees in lab techniques and protocols



Basic Qualifications

What you'll need:

College Background degree in biology, molecular biology, biochemistry, neuroscience or related field. Education may count towards years of experience.
1 or more years of experience with molecular and cellular biology techniques such as ELISA, western blots, or related experience.

Additional Qualifications and Skills

Desirable Skills:

Bachelors Degree strongly preferred
Previous experience and ability to operate independently
Previous knowledge and/or experience with rodent handling and tissue preparation is strongly preferred
Experience with tissue culture is a plus
Ability to work well independently and to collaborate with a multidisciplinary group
Should be highly motivated, detail-oriented, organized, and able to take initiative
Proficient with personal computers and applicable software packages (Microsoft Office).

Additional Information

Offer contingent on successful completion of pre-placement medical evaluation. This is a one year term position with the possibility of renewal.

Why you’ll like working with us:

At the Wyss Institute, you’re a member of a supportive, dynamic community that is united by its shared goal of changing the world through groundbreaking technology development and commercialization. We encourage your professional growth and development through mentorship and tuition reimbursement to support continued learning, and more. We also support your physical, financial, and mental well-being through generous time off benefits, gym reimbursements, and other programs offered through Harvard. We value an inclusive and diverse workforce, and believe that our differences enrich the work environment for all.

Harvard Medical School strives to cultivate an environment that promotes inclusiveness and collaboration among students, faculty and staff and to create new avenues for discussion that will advance our shared mission to improve the health of people throughout the world.


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