Post-doctoral research fellow

Brigham and Women's Hospital

Boston, MA

Job posting number: #7071778

Posted: November 4, 2020

Application Deadline: Open Until Filled

Job Description

This is a full time (>40h/wk; hours vary) protein biochemist post-doctoral fellow position in a cancer research lab at Brigham and Women's Hospital with a close relationship to Dana-Farber Cancer Institute. We focus entirely on a rare aggressive and incurable cancer called NUT carcinoma, a disease we characterized both genetically and clinically. This squamous cancer is driven by a fusion oncoprotein, BRD4-NUT. We have recently discovered a small molecule bromodomain inhibitor that exhibits impressive in vivo activity in NUT carcinoma, and hypothesize that it alters the composition of the BRD4-NUT-chromatin complex (not just evicting BRD4-NUT from chromatin). The project for this post-doc is focused. They will determine, by proteomic analysis, what changes in BRD4-NUT-interacting proteins occur upon exposure to this inhibitor compared with more selective inhibitors - we suspect many interactions are mediated by bromodomain-acetyl-lysine interaction. Our hypothesis is that critical BRD4-NUT-interacting proteins will be lost in the presence of the bromodomain inhibitor, revealing both mechanism of action and new therapeutic vulnerabilities in NUT carcinoma.
The position is fully funded for three years.



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